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Animal Bites |
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INTRODUCTION
Background: Estimates indicate that
more than 5 million Americans are bitten by
animals each year. Dogs and cats are involved
in most of these bites. Bites from both cats
and dogs require careful management, and
patients may experience long-term morbidity or
may even die. Cat bites have a high incidence
of infection (approximately 50%), and dog
bites may cause severe injury to tissues. Dog
and cat populations in the United States are
estimated to exceed 50 million animals each.
Many households in the United States include
pets, and many children are bitten by family
pets.
Breeds associated with serious dog bites in
children include pit bull, rottweiler, wolf
mix, Saint Bernard, German shepherd, and
Akita.
Pathophysiology:
Dogs and
cats have prominent canine teeth; however,
great differences exist in the structure of
those teeth. Dogs have wider canines, while
cats have thinner canines. Dogs are capable of
exerting enormous pressure while biting, and
some breeds can pierce metal plates with their
teeth. In particular, the bites of large dogs
can be dangerous to children. Large breeds
tend to cause wounds in the head and neck
areas of younger children, and their powerful
jaws can penetrate the skull and destroy deep
tissue. Cat bites are characterized by
puncture wounds that inoculate bacteria deeply
into tissues.
Cats and dogs harbor a number of
potentially pathogenic species of aerobic and
anaerobic bacteria in the oral flora. Common
genera include Staphylococcus,
Streptococcus, Pasteurella, and
Bacteroides. Other organisms cultured
in dog bites include Capnocytophaga
canimorsus and species of Eikenella,
Enterobacter, Proteus,
Haemophilus, and Klebsiella. Cat
bites may contain Actinomyces,
Fusobacterium, Peptostreptococcus,
Clostridium, Wolinella, and
Propionibacterium organisms.
Infections should be assumed to be
polymicrobial.
Frequency:
- In the US:
Estimates
indicate that more than 5 million Americans
are bitten by animals each year. Dog bites
account for nearly 85% and cat bites for
approximately 10% of the total number of
animal bites. Other animals involved in
bites include rodents and other small
mammals, such as ferrets and rabbits. Bites
from more exotic animals (eg, snakes,
lizards, monkeys, farm animals) are rare.
- Internationally:
Types
of animal bites can vary depending on land
development and the natural flora. For
example, in India, tiger bites may be
encountered. In general, in North America,
dogs are the agents in most animal bites.
Mortality/Morbidity:
Each
year, approximately 20 people die as a result
of dog bites. Most are young children who have
massive neck and head injuries resulting from
the bites. The mouths in breeds of large dogs
are at the height of young children's faces.
Pit bulls, with powerful jaws that are capable
of causing rapid and devastating damage, are
responsible for nearly three fourths of
fatalities.
- Wound infection and cellulitis resulting
from bacterial infections are the most
common causes of morbidity.
- Bite wounds in joint spaces may be
complicated by septic arthritis. Deep wounds
may be complicated by osteomyelitis, and
penetrating skull wounds may result in
meningitis.
- Although rare, rabies can be a fatal
complication of mammalian bites. The
possibility of rabies should be addressed in
the history.
Sex:
Males are more likely
than females to be bitten by dogs. Females are
more likely than males to be bitten by cats.
Age:
Animal bites are most
common in children aged 5-14 years.
CLINICAL
History:
Begin taking the history with
prehospital care.
- Important details in the history include
the type of animal that attacked the
patient, behavior of the animal, and time of
day the bite occurred. For instance, a
raccoon bite in the daytime places the
patient at higher risk of rabies exposure,
as does an unprovoked attack.
- Document the address or location of the
attack and the time of the attack
(important).
- Ascertain ownership of the animal,
current location of the animal, and rabies
vaccination status.
- Document prehospital care (eg, wound
cleansing).
- Document the patient's allergies,
current medications, medical history,
immunization status, and the time of the
last meal.
Physical:
- Focus physical examination initially on
the ABCs.
- Patients with animal bites rarely
require resuscitation.
- Ensure that no compromise of
circulation, motor skills, or sensation
exists.
- Inspect the wounds, paying careful
attention to soft tissue damage, tendon
exposure or injury, bone exposure, and the
presence of foreign bodies.
- Limitations of the physical examination
should be realized as follows:
- Cat bites may appear innocuous but may
violate joint space integrity.
- Dog bites to the head may penetrate
the skull, and foreign bodies (eg, teeth,
fragments of teeth) may not be detected by
examination.
Causes:
Bites may be
either provoked or unprovoked.
- Causes of provoked attacks
- Causes of unprovoked attacks
- Approaching the young of an animal
- Approaching an animal that is eating
- Entering the property of a territorial
animal
- Nearing an animal with rabies
- Dogs are pack animals. Many instances
have occurred in which individuals were
mauled by packs.
Other Problems to be Considered:
Wound infection
Cellulitis
Fractures
Foreign bodies
Meningitis
Cervical spine injury
Vascular injury
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WORKUP
Lab Studies:
- Laboratory testing is rarely helpful
when patients with dog bites present
immediately after injury. Hemodynamically
unstable patients are an obvious exception.
- Additional laboratory testing should be
performed as indicated. Usually, patients
presenting with infection require further
workup.
- Consider culturing tissue of a
nonseptic patient presenting with a wound
infection.
- Obtain a CBC and blood culture in
patients with more severe infections.
Imaging Studies:
- Radiographs generally are not helpful
but may be useful for certain bite wounds.
- Dog bites to the head may penetrate the
skull. At the minimum, obtain a skull
radiograph in a child with a dog bite to the
head, especially in a bite from a large dog.
- Foreign bodies, such as tooth fragments,
may be demonstrated on radiographs. Obtain a
radiograph if the possibility of a foreign
body cannot be excluded by examination.
- Patients with deep tissue injuries may
have fractures. The hand and joint spaces
are particularly vulnerable.
- Patients who present with signs of
infection may have osteomyelitis or septic
arthritis. Bone scans may reveal
osteomyelitis even in patients in whom
radiograph findings are negative.
- Children with penetrating skull injuries
should have a head CT scan.
Procedures:
- Joint aspiration may aid in the
diagnosis of septic arthritis.
TREATMENT
Medical
Care:
- Address ABCs immediately in the event of
facial and neck wounds.
- Wounds should be irrigated copiously
with isotonic sodium chloride solution under
high pressure (usually with an 18- or
19-gauge needle or angiocatheter). Wounds
may require more than 200 mL/in of isotonic
sodium chloride solution.
- Infection is a feared complication of
animal bites, especially cat bites. Studies
have shown that infections are polymicrobial.
Antibiotic coverage for staphylococci and
anaerobes is necessary.
- Consider tetanus prophylaxis.
- Consider rabies prophylaxis in certain
circumstances (eg, raccoon bites, bat bites,
unprovoked attack by an unknown animal).
Surgical Care:
Surgical
treatment may be appropriate.
- Debridement is useful for removing
foreign bodies and devitalized tissue, which
can serve as a nidus for infection. Remove
blood clots, and inspect the wound further
during the procedure.
- Careful wound excision may improve the
cosmetic appearance of the scar and decrease
the incidence of wound infection.
- Perform primary closure in certain
wounds. Facial wounds rarely become infected
because the face is well vascularized. Clean
wounds also can be closed. Wounds on the
hands or lower extremities should be left
open. Patients who have a wound older than 6
hours are treated best using delayed primary
closure in lieu of primary closure.
Consultations:
- Plastic surgeon for potentially
disfiguring injuries
- Hand specialist for injuries to the hand
- Orthopedist for bone and joint injuries
or deep structural injuries
- Neurosurgeon for penetrating wounds to
the skull
- Vascular specialist for neck wounds
- Infectious disease specialist for
immunocompromised patients
MEDICATION
Amoxicillin
combined with a beta-lactamase inhibitor is
the oral antibiotic used most frequently.
Patients who are allergic to penicillin and
are tolerant of cephalosporins may be treated
with ceftriaxone. Patients who are intolerant
to cephalosporins may be treated with a
combination of trimethoprim and
sulfamethoxazole plus clindamycin. Prophylaxis
also may be provided with erythromycin or a
tetracycline. A 3- to 7-day course of
antibiotic therapy commonly is used for
prophylaxis.
Drug Category:
Antibiotics -- Used for
prophylaxis and treatment of infection.
Empiric antimicrobial therapy must be
comprehensive and should cover all likely
pathogens in the context of the clinical
setting.
Drug Name
|
Amoxicillin clavulanate (Augmentin) --
Combination antibiotic containing
amoxicillin with a beta-lactamase
inhibitor, which extends the antibiotic
spectrum. Overall, the spectrum of this
antibiotic provides the best prophylaxis
against potential pathogens. Dose is based
on the amoxicillin content. |
| Adult Dose |
500
mg PO tid or 875 mg PO bid |
| Pediatric Dose |
<3
months: 30-40 mg/kg/d PO divided bid (use
125 mg/5 mL susp)
>3 months: 45 mg/kg/d PO divided q12h (use
200 or 400 mg/5 mL susp)
If 125 or 250 mg/5mL susp is used,
administer 40 mg/kg/d PO divided q8h
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| Contraindications |
Documented hypersensitivity; prior
Augmentin-induced hepatic dysfunction
|
| Interactions |
Coadministration with warfarin or heparin
increases risk of bleeding; probenecid may
inhibit renal tubular secretion of
amoxicillin, thus increasing levels |
| Pregnancy |
B -
Usually safe but benefits must outweigh
the risks. |
| Precautions |
Caution in liver dysfunction and
pseudomembranous colitis; administer with
food; common adverse reactions include
rash and gastrointestinal tract upset |
Drug Name
|
Ampicillin-sulbactam (Unasyn) -- Treatment
of choice for infected bites with a
spectrum similar to Augmentin. Contains
two-thirds ampicillin and one-third
sulbactam. Pediatric doses are based on
ampicillin component. |
| Adult Dose |
1.5 g
(1 g ampicillin plus 0.5 g sulbactam) IV
q6h |
| Pediatric Dose |
100-150 ampicillin/kg/d IV divided q6h
|
| Contraindications |
Documented hypersensitivity
|
| Interactions |
Probenecid and disulfiram elevate
ampicillin levels; allopurinol decreases
ampicillin effects and has additive
effects on ampicillin rash; may decrease
effects of oral contraceptives |
| Pregnancy |
B -
Usually safe but benefits must outweigh
the risks. |
| Precautions |
Pseudomembranous colitis; evaluate rash
and differentiate from hypersensitivity
reaction; adjust dose in renal failure |
Drug Name
|
Trimethoprim and sulfamethoxazole (Bactrim,
Septra) -- Used in combination with
clindamycin for prophylaxis or treatment
in patients allergic to penicillin.
Sulfamethoxazole inhibits bacterial
synthesis of dihydrofolic acid by
competing with para-aminobenzoic acid.
Trimethoprim blocks the production of
tetrahydrofolic acid by inhibiting the
enzyme dihydrofolate reductase. Two
consecutive steps in bacterial
biosynthesis of essential nucleic acids
and proteins are blocked with this
combination. In vitro bacterial resistance
is slower to develop with this combination
than with either drug alone.
|
| Adult Dose |
160
mg trimethoprim/800 mg sulfamethoxazole PO
q12h (ie, 1 double-strength tab q12h)
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| Pediatric Dose |
<2
months: Do not administer
>2 months: 8-10 mg/kg/d (based on
trimethoprim component) PO divided q12h
|
| Contraindications |
Documented hypersensitivity; anemia caused
by folate deficiency |
| Interactions |
May
increase PT when used with warfarin
(perform coagulation tests and adjust dose
accordingly); coadministration with
dapsone may increase blood levels of both
drugs; coadministration with diuretics
increases incidence of thrombocytopenia
purpura in elderly patients; phenytoin
levels may increase with coadministration;
may potentiate effects of methotrexate in
bone marrow depression; hypoglycemic
response to sulfonylureas may increase
with coadministration; may increase levels
of zidovudine |
| Pregnancy |
C -
Safety for use during pregnancy has not
been established. |
| Precautions |
Do
not use in pregnancy near term (risk of
kernicterus); may cause Stevens-Johnson
syndrome and toxic epidermal necrolysis;
discontinue at first appearance of rash or
signs of adverse reaction (eg, rash, sore
throat, fever, arthralgia, cough,
shortness of breath, pallor, purpura,
jaundice); hepatic necrosis; aplastic
anemia; agranulocytosis; hemolysis may
occur in patients with G-6-PD deficiency
(dose related); caution in renal or
hepatic impairment |
Drug Name
|
Clindamycin (Cleocin) -- Used for
prophylaxis and treatment of animal bites
in combination with TMP-SMZ; inhibits
bacterial protein synthesis by its action
at the bacterial ribosome; binds to 50S
ribosomal subunit and affects process of
peptide chain initiation. |
| Adult Dose |
150-450 mg PO q6-8h
1200-1800 mg IV divided tid/qid
|
| Pediatric Dose |
10-30
mg/kg/d PO divided tid/qid
25-40 mg/kg/d IV divided q6-8h
|
| Contraindications |
Documented hypersensitivity; regional
enteritis; ulcerative colitis; hepatic
impairment; antibiotic-associated colitis
|
| Interactions |
Increases duration of neuromuscular
blockade induced by tubocurarine and
pancuronium; erythromycin may antagonize
effects of clindamycin; antidiarrheals may
delay absorption of clindamycin |
| Pregnancy |
B -
Usually safe but benefits must outweigh
the risks. |
| Precautions |
Pseudomembranous colitis; adjust dose in
severe hepatic dysfunction; no adjustment
necessary in renal failure; advise
patients to take cap with full glass of
water |
Drug Name
|
Erythromycin (EES, E-Mycin, Ery-Tab,
Erythrocin) -- For prophylactic use in
patients allergic to penicillin; macrolide
antibiotic with a large spectrum of
activity; binds to 50S ribosomal subunit
to inhibit protein synthesis. |
| Adult Dose |
250-500 mg PO qid or 400-800 mg (ethylsuccinate)
PO tid |
| Pediatric Dose |
30-50
mg/kg/d PO divided q6-8h |
| Contraindications |
Documented hypersensitivity; hepatic
impairment; concomitant administration of
terfenadine (recalled from US market),
cisapride, or astemizole (recalled from
US market) |
| Interactions |
Decreases clearance of terfenadine
(recalled from US market), cisapride,
and astemizole (recalled from US
market), which may result in serious
cardiac arrhythmias; decreases clearance
of cyclosporine, midazolam, phenytoin,
triazolam, theophylline, and carbamazepine;
may increase warfarin toxicity |
| Pregnancy |
B -
Usually safe but benefits must outweigh
the risks. |
| Precautions |
Impaired hepatic function, abdominal pain,
diarrhea, nausea, and vomiting |
Drug Name
|
Ceftriaxone (Rocephin) -- Third-generation
cephalosporin with broad-spectrum
gram-negative activity; lower efficacy
against gram-positive organisms; higher
efficacy against resistant organisms.
Arrests bacterial growth by binding to one
or more penicillin-binding proteins.
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| Adult Dose |
Uncomplicated infections: 250 mg IM once;
not to exceed 4 g
Severe infections: 1-2 g IV qd or divided
bid; not to exceed 4 g/d
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| Pediatric Dose |
Neonates >7 days: 25-50 mg/kg/d IV/IM; not
to exceed 125 mg/d
Infants and children: 50-75 mg/kg/d IV/IM
divided q12h; not to exceed 2 g/d
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| Contraindications |
Documented hypersensitivity
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| Interactions |
Probenecid may increase ceftriaxone
levels; coadministration with ethacrynic
acid, furosemide, and aminoglycosides may
increase nephrotoxicity |
| Pregnancy |
B -
Usually safe but benefits must outweigh
the risks. |
| Precautions |
Adjust dose in severe renal insufficiency
(high doses may cause CNS toxicity);
superinfections and promotion of
nonsusceptible organisms may occur with
prolonged use or repeated therapy; caution
in breastfeeding |
Drug Name
|
Tetracycline (Sumycin) -- Treats
gram-positive and gram-negative organisms
as well as mycoplasmal, chlamydial, and
rickettsial infections. Inhibits bacterial
protein synthesis by binding with 30S and,
possibly, 50S ribosomal subunits. |
| Adult Dose |
250-500 mg PO q6h
Mild-to-moderate infections: 500 mg PO bid
or 250 mg PO qid for 7-14 d
Severe infections: 500 mg PO qid for 7-14
d
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| Pediatric Dose |
<8
years: Not recommended
>8 years: 25-50 mg/kg/d PO divided qid
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| Contraindications |
Documented hypersensitivity; severe
hepatic dysfunction |
| Interactions |
Bioavailability decreases with antacids
containing aluminum, calcium, magnesium,
iron, or bismuth subsalicylate; can
decrease effects of oral contraceptives,
causing breakthrough bleeding and
increased risk of pregnancy; tetracyclines
can increase hypoprothrombinemic effects
of anticoagulants |
| Pregnancy |
D -
Unsafe in pregnancy |
| Precautions |
Photosensitivity may occur with prolonged
exposure to sunlight or tanning equipment;
reduce dose in renal impairment; consider
drug serum level determinations in
prolonged therapy; tetracycline use during
tooth development (last one half of
pregnancy through age 8 y) can cause
permanent discoloration of teeth;
Fanconilike syndrome may occur with
outdated tetracyclines |
FOLLOW-UP
Further Inpatient Care:
- Patients requiring inpatient care
include those with airway compromise,
hemodynamic instability, penetrating skull
injury, or severe soft tissue injuries.
- Appropriate surgical subspecialties
should be involved in treating patients
admitted to the hospital. Decisions to
incise, drain, and explore tissue should be
made after surgical consultation.
- Patients who may not be compliant with
outpatient antibiotic therapy may require
admission. Patients who have developed signs
of infection may benefit from admission.
- If osteomyelitis is suspected despite
normal radiograph findings, consider a bone
scan.
Further Outpatient Care:
- Follow-up care is necessary within 24-48
hours for all bite wounds because of risk of
infection.
Transfer:
- Transfer patients who are
hemodynamically unstable, have airway
compromise, or have massive trauma to a
tertiary care center.
Deterrence/Prevention:
- Pet owners should watch animals when
children are present. Children should be
discouraged from approaching animals,
especially when the animal is not the family
pet. Children should avoid animals that are
eating.
- Citizens should insist on leash laws,
and pet owners should keep their animals on
a leash.
- Physicians can educate parents about the
potential dangers of certain breeds and the
need to be vigilant if they own a pet.
Complications:
Prognosis:
- Most patients with animal bites have a
good-to-excellent prognosis.
Patient Education:
- Patients and their families should
receive instructions that clearly outline
the signs of infection.
- Inform patients of the risk of infection
as a consequence of the animal bite despite
treatment with irrigation and antibiotics.
- Emphasize the need for follow-up care as
well as the need to receive immediate
medical attention if signs of infection
develop.
MISCELLANEOUS
Medical/Legal Pitfalls:
- Failure to consider the possibility of
skull penetration
- Failure to consider the possibility of
inoculation of bacteria into a joint space
- Improperly closing wounds (eg, cat bite
to the hand)
- Failure to adequately document the
patient's history
- Failure to adequately document treatment
(eg, irrigation, antibiotic use)
- Failure to report the injury to police
or the local animal control agency
Special Concerns:
- If the animal is a family pet, a danger
exists that it may attack the child again.
Consider discussing the removal of the pet
with the family.
- Dogs that are left off a leash and have
bitten individuals constitute a menace to
the community. Dogs should always be on a
leash. Aggressive dogs may require a muzzle.
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