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Animal Bites

INTRODUCTION
Background: Estimates indicate that more than 5 million Americans are bitten by animals each year. Dogs and cats are involved in most of these bites. Bites from both cats and dogs require careful management, and patients may experience long-term morbidity or may even die. Cat bites have a high incidence of infection (approximately 50%), and dog bites may cause severe injury to tissues. Dog and cat populations in the United States are estimated to exceed 50 million animals each. Many households in the United States include pets, and many children are bitten by family pets.

Breeds associated with serious dog bites in children include pit bull, rottweiler, wolf mix, Saint Bernard, German shepherd, and Akita.

Pathophysiology: Dogs and cats have prominent canine teeth; however, great differences exist in the structure of those teeth. Dogs have wider canines, while cats have thinner canines. Dogs are capable of exerting enormous pressure while biting, and some breeds can pierce metal plates with their teeth. In particular, the bites of large dogs can be dangerous to children. Large breeds tend to cause wounds in the head and neck areas of younger children, and their powerful jaws can penetrate the skull and destroy deep tissue. Cat bites are characterized by puncture wounds that inoculate bacteria deeply into tissues.

Cats and dogs harbor a number of potentially pathogenic species of aerobic and anaerobic bacteria in the oral flora. Common genera include Staphylococcus, Streptococcus, Pasteurella, and Bacteroides. Other organisms cultured in dog bites include Capnocytophaga canimorsus and species of Eikenella, Enterobacter, Proteus, Haemophilus, and Klebsiella. Cat bites may contain Actinomyces, Fusobacterium, Peptostreptococcus, Clostridium, Wolinella, and Propionibacterium organisms. Infections should be assumed to be polymicrobial.

Frequency:

  • In the US: Estimates indicate that more than 5 million Americans are bitten by animals each year. Dog bites account for nearly 85% and cat bites for approximately 10% of the total number of animal bites. Other animals involved in bites include rodents and other small mammals, such as ferrets and rabbits. Bites from more exotic animals (eg, snakes, lizards, monkeys, farm animals) are rare.
  • Internationally: Types of animal bites can vary depending on land development and the natural flora. For example, in India, tiger bites may be encountered. In general, in North America, dogs are the agents in most animal bites.

Mortality/Morbidity: Each year, approximately 20 people die as a result of dog bites. Most are young children who have massive neck and head injuries resulting from the bites. The mouths in breeds of large dogs are at the height of young children's faces. Pit bulls, with powerful jaws that are capable of causing rapid and devastating damage, are responsible for nearly three fourths of fatalities.

  • Wound infection and cellulitis resulting from bacterial infections are the most common causes of morbidity.
  • Bite wounds in joint spaces may be complicated by septic arthritis. Deep wounds may be complicated by osteomyelitis, and penetrating skull wounds may result in meningitis.
  • Although rare, rabies can be a fatal complication of mammalian bites. The possibility of rabies should be addressed in the history.

Sex: Males are more likely than females to be bitten by dogs. Females are more likely than males to be bitten by cats.

Age: Animal bites are most common in children aged 5-14 years.

CLINICAL
History: Begin taking the history with prehospital care.

  • Important details in the history include the type of animal that attacked the patient, behavior of the animal, and time of day the bite occurred. For instance, a raccoon bite in the daytime places the patient at higher risk of rabies exposure, as does an unprovoked attack.
  • Document the address or location of the attack and the time of the attack (important).
  • Ascertain ownership of the animal, current location of the animal, and rabies vaccination status.
  • Document prehospital care (eg, wound cleansing).
  • Document the patient's allergies, current medications, medical history, immunization status, and the time of the last meal.

Physical:

  • Focus physical examination initially on the ABCs.
    • Patients with animal bites rarely require resuscitation.
    • Ensure that no compromise of circulation, motor skills, or sensation exists.
    • Inspect the wounds, paying careful attention to soft tissue damage, tendon exposure or injury, bone exposure, and the presence of foreign bodies.
  • Limitations of the physical examination should be realized as follows:
    • Cat bites may appear innocuous but may violate joint space integrity.
    • Dog bites to the head may penetrate the skull, and foreign bodies (eg, teeth, fragments of teeth) may not be detected by examination.

Causes: Bites may be either provoked or unprovoked.

  • Causes of provoked attacks
    • Antagonizing an animal
    • Hurting an animal
  • Causes of unprovoked attacks
    • Approaching the young of an animal
    • Approaching an animal that is eating
    • Entering the property of a territorial animal
    • Nearing an animal with rabies
  • Dogs are pack animals. Many instances have occurred in which individuals were mauled by packs.

Other Problems to be Considered:

Wound infection
Cellulitis
Fractures
Foreign bodies
Meningitis
Cervical spine injury
Vascular injury

WORKUP
Lab Studies:

  • Laboratory testing is rarely helpful when patients with dog bites present immediately after injury. Hemodynamically unstable patients are an obvious exception.
  • Additional laboratory testing should be performed as indicated. Usually, patients presenting with infection require further workup.
    • Consider culturing tissue of a nonseptic patient presenting with a wound infection.
    • Obtain a CBC and blood culture in patients with more severe infections.

Imaging Studies:

  • Radiographs generally are not helpful but may be useful for certain bite wounds.
  • Dog bites to the head may penetrate the skull. At the minimum, obtain a skull radiograph in a child with a dog bite to the head, especially in a bite from a large dog.
  • Foreign bodies, such as tooth fragments, may be demonstrated on radiographs. Obtain a radiograph if the possibility of a foreign body cannot be excluded by examination.
  • Patients with deep tissue injuries may have fractures. The hand and joint spaces are particularly vulnerable.
  • Patients who present with signs of infection may have osteomyelitis or septic arthritis. Bone scans may reveal osteomyelitis even in patients in whom radiograph findings are negative.
  • Children with penetrating skull injuries should have a head CT scan.

Procedures:

  • Joint aspiration may aid in the diagnosis of septic arthritis.

TREATMENT
Medical Care:

  • Address ABCs immediately in the event of facial and neck wounds.
  • Wounds should be irrigated copiously with isotonic sodium chloride solution under high pressure (usually with an 18- or 19-gauge needle or angiocatheter). Wounds may require more than 200 mL/in of isotonic sodium chloride solution.
  • Infection is a feared complication of animal bites, especially cat bites. Studies have shown that infections are polymicrobial. Antibiotic coverage for staphylococci and anaerobes is necessary.
  • Consider tetanus prophylaxis.
  • Consider rabies prophylaxis in certain circumstances (eg, raccoon bites, bat bites, unprovoked attack by an unknown animal).

Surgical Care: Surgical treatment may be appropriate.

  • Debridement is useful for removing foreign bodies and devitalized tissue, which can serve as a nidus for infection. Remove blood clots, and inspect the wound further during the procedure.
  • Careful wound excision may improve the cosmetic appearance of the scar and decrease the incidence of wound infection.
  • Perform primary closure in certain wounds. Facial wounds rarely become infected because the face is well vascularized. Clean wounds also can be closed. Wounds on the hands or lower extremities should be left open. Patients who have a wound older than 6 hours are treated best using delayed primary closure in lieu of primary closure.

Consultations:

  • Plastic surgeon for potentially disfiguring injuries
  • Hand specialist for injuries to the hand
  • Orthopedist for bone and joint injuries or deep structural injuries
  • Neurosurgeon for penetrating wounds to the skull
  • Vascular specialist for neck wounds
  • Infectious disease specialist for immunocompromised patients

MEDICATION
Amoxicillin combined with a beta-lactamase inhibitor is the oral antibiotic used most frequently. Patients who are allergic to penicillin and are tolerant of cephalosporins may be treated with ceftriaxone. Patients who are intolerant to cephalosporins may be treated with a combination of trimethoprim and sulfamethoxazole plus clindamycin. Prophylaxis also may be provided with erythromycin or a tetracycline. A 3- to 7-day course of antibiotic therapy commonly is used for prophylaxis.
 

Drug Category: Antibiotics -- Used for prophylaxis and treatment of infection. Empiric antimicrobial therapy must be comprehensive and should cover all likely pathogens in the context of the clinical setting.

Drug Name
 
Amoxicillin clavulanate (Augmentin) -- Combination antibiotic containing amoxicillin with a beta-lactamase inhibitor, which extends the antibiotic spectrum. Overall, the spectrum of this antibiotic provides the best prophylaxis against potential pathogens. Dose is based on the amoxicillin content.
Adult Dose 500 mg PO tid or 875 mg PO bid
Pediatric Dose <3 months: 30-40 mg/kg/d PO divided bid (use 125 mg/5 mL susp)
>3 months: 45 mg/kg/d PO divided q12h (use 200 or 400 mg/5 mL susp)

If 125 or 250 mg/5mL susp is used, administer 40 mg/kg/d PO divided q8h
Contraindications Documented hypersensitivity; prior Augmentin-induced hepatic dysfunction
Interactions Coadministration with warfarin or heparin increases risk of bleeding; probenecid may inhibit renal tubular secretion of amoxicillin, thus increasing levels
Pregnancy B - Usually safe but benefits must outweigh the risks.
Precautions Caution in liver dysfunction and pseudomembranous colitis; administer with food; common adverse reactions include rash and gastrointestinal tract upset
Drug Name
 
Ampicillin-sulbactam (Unasyn) -- Treatment of choice for infected bites with a spectrum similar to Augmentin. Contains two-thirds ampicillin and one-third sulbactam. Pediatric doses are based on ampicillin component.
Adult Dose 1.5 g (1 g ampicillin plus 0.5 g sulbactam) IV q6h
Pediatric Dose 100-150 ampicillin/kg/d IV divided q6h
Contraindications Documented hypersensitivity
Interactions Probenecid and disulfiram elevate ampicillin levels; allopurinol decreases ampicillin effects and has additive effects on ampicillin rash; may decrease effects of oral contraceptives
Pregnancy B - Usually safe but benefits must outweigh the risks.
Precautions Pseudomembranous colitis; evaluate rash and differentiate from hypersensitivity reaction; adjust dose in renal failure
Drug Name
 
Trimethoprim and sulfamethoxazole (Bactrim, Septra) -- Used in combination with clindamycin for prophylaxis or treatment in patients allergic to penicillin.
Sulfamethoxazole inhibits bacterial synthesis of dihydrofolic acid by competing with para-aminobenzoic acid. Trimethoprim blocks the production of tetrahydrofolic acid by inhibiting the enzyme dihydrofolate reductase. Two consecutive steps in bacterial biosynthesis of essential nucleic acids and proteins are blocked with this combination. In vitro bacterial resistance is slower to develop with this combination than with either drug alone.
Adult Dose 160 mg trimethoprim/800 mg sulfamethoxazole PO q12h (ie, 1 double-strength tab q12h)
Pediatric Dose <2 months: Do not administer
>2 months: 8-10 mg/kg/d (based on trimethoprim component) PO divided q12h
Contraindications Documented hypersensitivity; anemia caused by folate deficiency
Interactions May increase PT when used with warfarin (perform coagulation tests and adjust dose accordingly); coadministration with dapsone may increase blood levels of both drugs; coadministration with diuretics increases incidence of thrombocytopenia purpura in elderly patients; phenytoin levels may increase with coadministration; may potentiate effects of methotrexate in bone marrow depression; hypoglycemic response to sulfonylureas may increase with coadministration; may increase levels of zidovudine
Pregnancy C - Safety for use during pregnancy has not been established.
Precautions Do not use in pregnancy near term (risk of kernicterus); may cause Stevens-Johnson syndrome and toxic epidermal necrolysis; discontinue at first appearance of rash or signs of adverse reaction (eg, rash, sore throat, fever, arthralgia, cough, shortness of breath, pallor, purpura, jaundice); hepatic necrosis; aplastic anemia; agranulocytosis; hemolysis may occur in patients with G-6-PD deficiency (dose related); caution in renal or hepatic impairment
Drug Name
 
Clindamycin (Cleocin) -- Used for prophylaxis and treatment of animal bites in combination with TMP-SMZ; inhibits bacterial protein synthesis by its action at the bacterial ribosome; binds to 50S ribosomal subunit and affects process of peptide chain initiation.
Adult Dose 150-450 mg PO q6-8h
1200-1800 mg IV divided tid/qid
Pediatric Dose 10-30 mg/kg/d PO divided tid/qid
25-40 mg/kg/d IV divided q6-8h
Contraindications Documented hypersensitivity; regional enteritis; ulcerative colitis; hepatic impairment; antibiotic-associated colitis
Interactions Increases duration of neuromuscular blockade induced by tubocurarine and pancuronium; erythromycin may antagonize effects of clindamycin; antidiarrheals may delay absorption of clindamycin
Pregnancy B - Usually safe but benefits must outweigh the risks.
Precautions Pseudomembranous colitis; adjust dose in severe hepatic dysfunction; no adjustment necessary in renal failure; advise patients to take cap with full glass of water
Drug Name
 
Erythromycin (EES, E-Mycin, Ery-Tab, Erythrocin) -- For prophylactic use in patients allergic to penicillin; macrolide antibiotic with a large spectrum of activity; binds to 50S ribosomal subunit to inhibit protein synthesis.
Adult Dose 250-500 mg PO qid or 400-800 mg (ethylsuccinate) PO tid
Pediatric Dose 30-50 mg/kg/d PO divided q6-8h
Contraindications Documented hypersensitivity; hepatic impairment; concomitant administration of terfenadine (recalled from US market), cisapride, or astemizole (recalled from US market)
Interactions Decreases clearance of terfenadine (recalled from US market), cisapride, and astemizole (recalled from US market), which may result in serious cardiac arrhythmias; decreases clearance of cyclosporine, midazolam, phenytoin, triazolam, theophylline, and carbamazepine; may increase warfarin toxicity
Pregnancy B - Usually safe but benefits must outweigh the risks.
Precautions Impaired hepatic function, abdominal pain, diarrhea, nausea, and vomiting
Drug Name
 
Ceftriaxone (Rocephin) -- Third-generation cephalosporin with broad-spectrum gram-negative activity; lower efficacy against gram-positive organisms; higher efficacy against resistant organisms. Arrests bacterial growth by binding to one or more penicillin-binding proteins.
Adult Dose Uncomplicated infections: 250 mg IM once; not to exceed 4 g
Severe infections: 1-2 g IV qd or divided bid; not to exceed 4 g/d
Pediatric Dose Neonates >7 days: 25-50 mg/kg/d IV/IM; not to exceed 125 mg/d
Infants and children: 50-75 mg/kg/d IV/IM divided q12h; not to exceed 2 g/d
Contraindications Documented hypersensitivity
Interactions Probenecid may increase ceftriaxone levels; coadministration with ethacrynic acid, furosemide, and aminoglycosides may increase nephrotoxicity
Pregnancy B - Usually safe but benefits must outweigh the risks.
Precautions Adjust dose in severe renal insufficiency (high doses may cause CNS toxicity); superinfections and promotion of nonsusceptible organisms may occur with prolonged use or repeated therapy; caution in breastfeeding
Drug Name
 
Tetracycline (Sumycin) -- Treats gram-positive and gram-negative organisms as well as mycoplasmal, chlamydial, and rickettsial infections. Inhibits bacterial protein synthesis by binding with 30S and, possibly, 50S ribosomal subunits.
Adult Dose 250-500 mg PO q6h
Mild-to-moderate infections: 500 mg PO bid or 250 mg PO qid for 7-14 d

Severe infections: 500 mg PO qid for 7-14 d
Pediatric Dose <8 years: Not recommended
>8 years: 25-50 mg/kg/d PO divided qid
Contraindications Documented hypersensitivity; severe hepatic dysfunction
Interactions Bioavailability decreases with antacids containing aluminum, calcium, magnesium, iron, or bismuth subsalicylate; can decrease effects of oral contraceptives, causing breakthrough bleeding and increased risk of pregnancy; tetracyclines can increase hypoprothrombinemic effects of anticoagulants
Pregnancy D - Unsafe in pregnancy
Precautions Photosensitivity may occur with prolonged exposure to sunlight or tanning equipment; reduce dose in renal impairment; consider drug serum level determinations in prolonged therapy; tetracycline use during tooth development (last one half of pregnancy through age 8 y) can cause permanent discoloration of teeth; Fanconilike syndrome may occur with outdated tetracyclines

FOLLOW-UP
Further Inpatient Care:

  • Patients requiring inpatient care include those with airway compromise, hemodynamic instability, penetrating skull injury, or severe soft tissue injuries.
  • Appropriate surgical subspecialties should be involved in treating patients admitted to the hospital. Decisions to incise, drain, and explore tissue should be made after surgical consultation.
  • Patients who may not be compliant with outpatient antibiotic therapy may require admission. Patients who have developed signs of infection may benefit from admission.
  • If osteomyelitis is suspected despite normal radiograph findings, consider a bone scan.

Further Outpatient Care:

  • Follow-up care is necessary within 24-48 hours for all bite wounds because of risk of infection.

Transfer:

  • Transfer patients who are hemodynamically unstable, have airway compromise, or have massive trauma to a tertiary care center.

Deterrence/Prevention:

  • Pet owners should watch animals when children are present. Children should be discouraged from approaching animals, especially when the animal is not the family pet. Children should avoid animals that are eating.
  • Citizens should insist on leash laws, and pet owners should keep their animals on a leash.
  • Physicians can educate parents about the potential dangers of certain breeds and the need to be vigilant if they own a pet.

Complications:

  • Meningitis
  • Sepsis
  • Septic arthritis
  • Osteomyelitis
  • Cellulitis
  • Wound infection
  • Facial/neck deformities
  • Limb deformities
  • Limb loss

Prognosis:

  • Most patients with animal bites have a good-to-excellent prognosis.

Patient Education:

  • Patients and their families should receive instructions that clearly outline the signs of infection.
  • Inform patients of the risk of infection as a consequence of the animal bite despite treatment with irrigation and antibiotics.
  • Emphasize the need for follow-up care as well as the need to receive immediate medical attention if signs of infection develop.

MISCELLANEOUS
Medical/Legal Pitfalls:

  • Failure to consider the possibility of skull penetration
  • Failure to consider the possibility of inoculation of bacteria into a joint space
  • Improperly closing wounds (eg, cat bite to the hand)
  • Failure to adequately document the patient's history
  • Failure to adequately document treatment (eg, irrigation, antibiotic use)
  • Failure to report the injury to police or the local animal control agency

Special Concerns:

  • If the animal is a family pet, a danger exists that it may attack the child again. Consider discussing the removal of the pet with the family.
  • Dogs that are left off a leash and have bitten individuals constitute a menace to the community. Dogs should always be on a leash. Aggressive dogs may require a muzzle.
 

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